Studies on Digitalis Glycosides. On the new Glycosides

Phenylethanoid Glycosides from Digitalis viridiflora

From the MeOH extract of the leaves of Digitalis viridiflora five phenylethanoid glycosides (1-5) including a new one were isolated. The structure of the new compound was established as 3,4-dihydroxy-βphenylethoxy-O-β-quinovopyranosyl-(16)-4-O-caffeoyl-β-glucopyranoside (viridifloroside, 1) based on extensive 1Dand 2D-NMR spectroscopy as well as MS. Compound 1 is the first example of a phenyle...

DIGITALIS & RELATED CARDIAC GLYCOSIDES Background

in the following notes the term digitalis is used to describe the entire group of cardiac glycosides a large number of plants contain cardiac glycosides, and these have been used by natives as arrow and ordeal poisons Squill was known to the ancient Egyptians and the Romans used it as a diuretic, heart tonic, emetic and rat poison Strophanthus was introduced by Sir Thomas Fraser in 1890 digital...

The cardioactive metabolites of digitalis glycosides.

There is little known about the nature of the metabolic products derived from cardiac glycosides in the animal body. Reports of the formation of digitoxigenin from the glycoside digitoxin in vivo have appeared in the literature (l-3), but reliable chemical methods of identification applicable to the very small quantities of material involved were not available to these workers. Fischer, Sjoerds...

Acute hypertensive effect of digitalis glycosides.

reentrant tachycardia. Micro-reentry within the peripheral ramifications of the Purkinje system, and at Purkinje fiber-ventricular muscle junctions has been demonstrated in a variety of experimental preparations.13-l5 In each case the essential requirement has been the establishment of inhomogeneous conduction and unidirectional block. The arrhythmias generated in these laboratory models have a...

Measurement of serum digitalis glycosides: clinical implications.